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- For the convenience of description, this website will refer to all anti-aging drugs, supplements and substances as supplements.
The 26 supplements after filtering and screening have no priority. They are all recognized by research institutions to extend life. The most detailed research reports can be found through online search.
The screening and determination of these 26 supplements does not deny the efficacy of other supplements in extending life. The screening is only to reduce the duplication of efficacy and cover various life extension targets more comprehensively;
According to the experience of people who have taken them, there are many ways to group supplements:
1.Grouping by the half-life of the supplements，
2.Grouping by the life extension target of the supplements，
3.Grouping by the bioavailability of the supplements，
4. Grouping according to your own physical condition and metabolic tolerance，
;
Regardless of which grouping, it should be noted that all supplements cannot be taken in one period of time, which will cause stomach discomfort and cause the supplements to conflict and inhibit each other during the absorption process, and lose their effectiveness;
The following grouping is roughly divided according to the unique mode of action of the supplements. It is not very strict and accurate. There are several point supplements that are basically orphans. In the absence of obvious conflicts, they are simply merged. Many users have made adjustments based on their own situations and understandings before taking the supplements.
It costs hundreds of dollars to buy all the 20 kinds of supplements. You can look for them online, some places are relatively cheap. However, it should be noted that you must not avoid buying fakes; also pay attention to try to choose supplements that are consistent with the name. Pure supplements mixed with other ingredients may cause conflicts in efficacy. Buy the lowest dose. Anti-aging supplements are not cold medicines that can be taken a few times. This is a long-term, low-dose, multi-target use.
The following nearly 30 kinds of supplements are divided into four groups for five target sites.
Rapamycin, EGCG, isoliquiritigenin, NAD+, quercetin, curcumin, black pepper, vitamin D3, vitamin A, berberine, PQQ, lithium, α-ketoglutarate, coenzyme Q10, fisetin, taurine, spermidine, glycine, threonine, AMPK, chondroitin sulfate, selenorutin, resveratrol + pterostilbene, coumarin, bitter melon extract, shogaol, lutein, nutmeg
Among them, rapamycin was not selected, mainly because of its large side effects and no mature control methods, and also because of its high price, which ordinary people cannot afford. Isoliquiritigenin is a rapamycin analogue, with a common price. There are also papers discussing its replacement of rapamycin, but the quantity is small and the safety is unclear. It is unlikely to be included in the use before more research articles are published. Another one is coumarin, which has a reliable paper as the background and the mechanism of intervention in the life span of mice is also clear. The problem is that there is no suitable formed supplement yet. Some people have tried using cinnamon extract as a substitute, but there is no definitive conclusion on its safety and efficacy.
1) Targeting mTOR
Taurine, lithium, AKG, vitamin D3, isoliquiritigenin, curcumin, vitamin A
(Rapamycin is not selected here, but its analogs are used, mainly because rapamycin is too expensive and not easy to obtain.
2) Targeting downstream S6K1 and Pol III
Resveratrol (or pterostilbene), EGCG (or halofuginone), threonine AMPK betaine, berberine
3) eNAMPT circulating level
NAD+ (or NMN+H)
4) Elimination of senescent cells induced autophagy
Quercetin+(black pepper), fisetin, gingerol. Glycine, astaxanthin, spermidine, proanthocyanidin C1
5) IL-11 inhibition and cell organization
Omega-3, Retin, Coenzyme 10, Chondroitin sulfate, Lutein, PQQ, Selenium, Nutmeg
The third group only has NAD+, which can be combined with the second group. There are four groups in total.
When taking these supplements, you must consider your age and current health status. Some people take one group each morning and afternoon on an empty stomach, and take four groups in two days. This may be safer.
If you feel uncomfortable during the process of taking it, you should stop taking it. You can also choose two or three in each group to take. You should not take supplements at the same time as other medicines you take. Don't take such things too seriously. After all, extending life is just an easy and pleasant goal. The future is promising, but what the future will be like is really unclear at present. If you don't have confidence and expectations, you don't have to spend the money and effort. A few hundred dollars to find a good restaurant and open a bottle of good wine is also a kind of life.
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