The so-called multi-target means that in the process of intervening life span, we insist on placing targets in multiple locations. Taking our current practice as an example, although the way, level, and intensity of the rapamycin target mTOR affecting human life span are very clear, and the operating environment is also very smooth, the forces that affect human life span come from many aspects, and relying solely on mTOR cannot guarantee that human life span can be extended. Therefore, it should be a correct choice to expand the intervention targets and focus on mTOR, S6K, Il-11, MAPK, ROS signaling, cell aging, calorie restriction, etc. Multi-direction, multi-path, setting multiple intervention targets will definitely increase the chance of success;

The so-called low dose refers to supplements that interfere with life span. Since we use multiple targets, the number of supplements used is relatively much larger. High-dose supplements may be more effective, but not necessarily. When multiple drugs are used in combination, the first thing to consider is safety. Low-dose combination supplements will have a milder effect and a long-lasting effect, and are unlikely to inhibit or conflict with each other. Of course, this also involves the price issue we have mentioned many times. In the current supplement market, the pricing principle involves the issue of dosage. Combination supplements are time-dependent and do not require such a high dose. High doses of supplements not only increase costs, but also reduce safety and may not necessarily improve efficacy.

Long-term issues are highly technical issues in anti-aging and lifespan intervention surgery. The effect of supplements depends entirely on what time of day you take them. At present, long-term does not refer to this issue. This means that if you want to implement lifespan intervention, you must be prepared to take these products continuously or intermittently for months, years, or even decades. All functions of the human body, especially the aging mechanism and lifespan mechanism, have strong genetic protection and trend protection capabilities. This trend inertia allows it to return to its original position in a very short time after being abnormally disturbed and changed. Whether you are 55, 70 or 85 years old now, your intervention behavior in lifespan can only be limited, intermittent, or even unsustainable. Unless you give up, or scientific progress discovers a more direct and simple technology to extend lifespan, this supplementary intervention will eventually accompany you throughout your life.

This is the principle of 2DC. If you want to extend your lifespan, you have to spend some time and energy.

At this point, some friends may ask, what is life extension?
There should be a standardized and strict concept of life extension. The so-called extension of life must have a starting point, that is, from the moment my life is "extended", there should be a clear definition.

According to the actual situation of each country, the life span of human beings should basically be based on the data released by the United Nations Population Department. The life expectancy of the population of each country is the basic life span, and the life span extended by some method should be the number of years after the expected life span. The more scientific approach is to add another 3 years to the number of years after the national population life expectancy (excluding malignant lesions, cancer and specific infectious diseases), which is to extend life.