The permanent termination of a stable operating cycle is the most obvious feature of cell aging. Once a cell enters the aging state, it still exists, but there is no longer any division process.

When people are young, about 25 or 26 years old, senescent cells also occur. However, the physiological functions full of youthful vitality, through autophagy, annihilate most of the senescent cells. At this time, there are not many senescent cells stored. Then, as people age, roughly from the age of 37, or in their early 40s, due to the vitality of people, the ability of autophagy to dissolve senescent cells has been greatly reduced, and senescent cells begin to accumulate gradually, posing a major crisis to human health.

Because necrotic cells have become a burden on various organs of the human body, the normal functions of many organs have been terminated. In particular, these cell states, although they no longer divide, have not stopped their activities. In addition to occupying the operating position of human organs and hindering their healthy operation, they also send weakening and death patterns to neighboring cells and organs from time to time, thereby accelerating human aging. Although some studies have found that senescent cells still have a role at a certain time and in a specific organ position, most of the elderly diseases of the human body are related to aging, especially senescent cells. From the perspective of life expression, senescent cells are the primary driving force that pushes life to its end.

In an experiment, researchers at the University of Connecticut used mice that were given P21 overexpression regularly (once a month) for 20 months to eliminate the disease. As a result, the mice's heart and metabolic function were successfully improved, and the average and maximum lifespan of the mice were extended. For humans, clearing senescent cells also has the benefits of promoting health and extending life (4).

As for the method of clearing senescent cells, we will not use the protein clearing method used by research institutions. What we use are basically some relatively safe and relatively broad supplements and small molecule drugs.

D+Q is the most commonly used and effective combination of drugs for clearing senescent cells. D refers to Dasatinib and Q refers to Quecertin. Dasatinib is a prescription drug (although it can be purchased on the market); Quecertin is a supplement with restrictions on online and over-the-counter sales. Fiseton is a substance that was initially discovered by the Mayo Clinic to clear senescent cells. It is cheap and easy to buy. After a lot of research tests, it was found that its ability to remove aging cells and its effect on certain aging-related diseases is quite good. However, the bioavailability needs to be improved. This can be achieved through the combination of cell configuration.

1. https://pmc.ncbi.nlm.nih.gov/articles/PMC4845101/ Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

2. https://www.nature.com/articles/s41591-022-01923-y Cellular senescence and senolytics: the path to the clinic

3. https://blog.cellsignal.com/10-must-have-markers-for-senescence-research? 10 Must-have Markers for Senescence Research

4. https://pubmed.ncbi.nlm.nih.gov/35024619/ ?An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo