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SIRT6 is a member of the protein deacetylase family. This family has 7 branches, SIRT1 to SIRT7. SIRT6 is a chromatin-associated protein located in the nucleus and is an NAD+-dependent histone deacetylase.
The prominent role of SIRT6 is that NAD repairs and regulates a variety of cellular processes, including metabolism, aging, and related physiological fluctuations. When accelerated aging causes chromatin structure and epigenetic changes, Sirt6 repairs DNA to stabilize protein homeostasis and slow down the rate of aging.
Activating Sirt6 can prevent the occurrence of frailty in the elderly and restore the vitality of the intracellular and extracellular domains, including normal blood sugar and decreased GNG capacity that occur with aging;
SIRT6 overexpression can effectively extend the lifespan of mice. According to a study by Bar-Ilan University in Ramat-Gan, Israel, compared with wild-type mice, after SIRT6 was overexpressed in transgenic mice, the lifespan of male and female mice was extended by 27% and 15%, respectively. The results here are not gender-specific and the difference between old and young is not obvious, which shows the strength and wide adaptability of Sirt6 overexpression in regulating lifespan.
SIRT6 maintains NAD+ levels and increases the expression of de novo NAD+ synthesis genes, so that the liver NAD+ level and GNG capacity metabolic function are always kept at normal levels, thereby inhibiting the occurrence of weakness. This is a natural and inevitable result.
Sirt6's ability to extend lifespan is achieved, to a certain extent, by reducing dMyc activity. Myc is the main regulator of protein synthesis. Under its unique role, the sharp decline in protein synthesis leads to a variety of harmful cellular processes such as genome instability and loss of protein homeostasis. Reducing dMyc activity makes the body's signal pathways connected, and the induction of mTOR, insulin/IGF-1, and AMP kinase is more accurate. Thus, it can send out stronger signals and promote life extension.
Sirt6 activation can be achieved through calorie restriction. This also shows the positive effect of calorie restriction on life extension from another aspect. Of course, there are many channels to activate Sirt6, such as nutmeg, pterostilbene, quercetin, etc. in our grouped supplements. According to relevant research reports, anthocyanins can not only activate SIRT6, but also increase its intensity by more than 10 times. This provides great convenience for using SIRT6 to intervene in lifespan.
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